DSSR-PyMOL cartoon-block schematics: PDB entry 6tcg

PDB-id

6tcg; DSSR-derived features in text and JSON formats

Class

DNA

Method

NMR

Summary

2'-f-riboguanosine and 2'-f-arabinoguanosine modified g-quadruplex with v-loop and all-syn g-tract

Reference

Haase L, Weisz K (2020): "Switching the type of V-loop in sugar-modified G-quadruplexes through altered fluorine interactions." Chem.Commun.(Camb.), 56, 4539-4542. doi: 10.1039/d0cc01285h.

Abstract

Mixed 2'-F-riboguanosine and 2'-F-arabinoguanosine disubstitutions of a hybrid-type G-quadruplex are found to induce a refolding into two alternative structures with different types of V-loops upon positional exchange of the two G analogs. While conformational preferences of the incorporated G surrogates fail to fully account for the observed rearrangements, additional hydrogen bonds with a fluorine acceptor are suggested to be critical determinants of the two distinct V-loop conformers imposing different tetrad polarities.