Summary information and primary citation
- PDB-id
-
4c5x;
SNAP-derived features in text and
JSON formats
- Class
- DNA
- Method
- X-ray (1.3 Å)
- Summary
- Ultra high resolution dickerson-drew dodecamer b-DNA
with 5-hydroxymethyl-cytosine modification
- Reference
-
Lercher L, McDonough MA, El-Sagheer AH, Thalhammer A,
Kriaucionis S, Brown T, Schofield CJ (2014): "Structural
insights into how 5-hydroxymethylation influences
transcription factor binding." Chem. Commun.
(Camb.), 50, 1794-1796. doi:
10.1039/c3cc48151d.
- Abstract
- Transcription factor binding and high resolution
crystallographic studies (1.3 Å) of Dickerson-Drew duplexes
with cytosine, methylcytosine and hydroxymethylcytosine
bases provide evidence that C-5 cytosine modifications
could regulate transcription by context dependent effects
on DNA transcription factor interactions.
