Summary information and primary citation
- PDB-id
-
2kmj;
SNAP-derived features in text and
JSON formats
- Class
- RNA-peptide
- Method
- NMR
- Summary
- High resolution NMR solution structure of a complex of
hiv-2 tar RNA and a synthetic tripeptide in a 1:2
stoichiometry
- Reference
-
Ferner J, Suhartono M, Breitung S, Jonker HRA, Hennig M,
Wohnert J, Gobel M, Schwalbe H (2009): "Structures
of HIV TAR RNA-ligand complexes reveal higher binding
stoichiometries." Chembiochem,
10, 1490-1494. doi: 10.1002/cbic.200900220.
- Abstract
- Target TAR by NMR: Tripeptides containing arginines as
terminal residues and non-natural amino acids as central
residues are good leads for drug design to target the HIV
trans-activation response element (TAR). The structural
characterization of the RNA-ligand complex by NMR
spectroscopy reveals two specific binding sites that are
located at bulge residue U23 and around the
pyrimidine-stretch U40-C41-U42 directly adjacent to the
bulge.
