Summary information and primary citation
- PDB-id
-
1d96;
SNAP-derived features in text and
JSON formats
- Class
- DNA-RNA hybrid
- Method
- X-ray (2.0 Å)
- Summary
- Molecular structure of r(gcg)d(tatacgc): a DNA-RNA
hybrid helix joined to double helical DNA
- Reference
-
Wang AH, Fujii S, van Boom JH, van der Marel GA, van
Boeckel SA, Rich A (1982): "Molecular
structure of r(GCG)d(TATACGC): a DNA--RNA hybrid helix
joined to double helical DNA." Nature,
299, 601-604. doi: 10.1038/299601a0.
- Abstract
- The molecule r(GCG)d(TATACGC) is self-complementary and
forms two DNA--RNA hybrid segments surrounding a central
region of double helical DNA; its molecular structure has
been solved by X-ray analysis. All three parts of the
molecule adopt a conformation which is close to that seen
in the 11-fold RNA double helix. The conformation of the
ribonucleotides is partly determined by water molecules
bridging between the ribose O2' hydroxyl group and cytosine
O2. The hybrid-DNA duplex junction contains no structural
discontinuities. However, the central DNA TATA sequence has
some structural irregularities.
