Summary information and primary citation
- PDB-id
-
176d;
SNAP-derived features in text and
JSON formats
- Class
- peptide nucleic acid-RNA
- Method
- NMR
- Summary
- NMR solution structure of a peptide nucleic acid
complexed with RNA
- Reference
-
Brown SC, Thomson SA, Veal JM, Davis DG (1994): "NMR
solution structure of a peptide nucleic acid complexed
with RNA." Science, 265,
777-780.
- Abstract
- Peptide nucleic acids (PNA) incorporating nucleic acid
bases into an achiral polyamide backbone bind to DNA in a
sequence-dependent manner. The structure of a
PNA-ribonucleic acid (RNA) complex was determined with
nuclear magnetic resonance methods. A hexameric PNA formed
a 1:1 complex with a complementary RNA that is an
antiparallel, right-handed double helix with Watson-Crick
base pairing similar to the "A" form structure of RNA
duplexes. The achiral PNA backbone assumed a distinct
conformation upon binding that differed from previously
proposed models and provides a basis for further
structure-based design of antisense agents.
